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Powerful molecule regulator in blood pressure control system discovered | Nitric oxide has been discovered as a powerful regulator of a molecule that plays a critical role in the evelopment and function of the nervous system, according to researchers at Oregon Health & Science University 's School of Dentistry. The discovery could someday play a significant role in the prevention and treatment
of high blood pressure, which affects about one in three adults in the United
States . Changes in blood pressure are signalled to the brain by nerve cells called
baroreceptors. In an earlier study, the researchers found that baroreceptors make
a molecule called brain-derived neurotrophic factor (BDNF), which belongs to the
family of neurotrophins that play a critical role in the development and plasticity
of other nerve cells. The researchers found that nitric oxide is a potent regulator
of BDNF in baroreceptor neurons. Nitric oxide is known for its ability to improve
the elasticity of blood vessels and to lower blood pressure. It is the active
metabolite of nitroglycerin, which has been used to treat coronary artery disease
for more than 100 years. Nitric oxide widens small arteries and counteracts artery
stiffening, and several lines of evidence also indicate that its deficiency leads
to hypertension. "This is the first study to show the role of nitric oxide in
inhibiting BDNF release from peripheral nerve cells. This finding supports our
hypothesis that BDNF is involved in establishing connections in the blood pressure
control system and could someday play a significant role in the prevention of
high blood pressure," said Dr. Agnieszka Balkowiec, principal investigator. The
study has been published in the Journal of Neuroscience Research. |
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