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Extreme and moderate heat may help cure tumours | According to a new research treating tumors with extreme heat or moderate heat, aided by ultrasound guidance, may provide a possible therapeutic option. Osama M. Al-Bataineh, an assistant professor in
biomedical engineering at the Hashemite University in Jordan , said: "Low temperature
controlled hyperthermia and high temperature treatments are beneficial in curing
both malignant and benign tumors using minimally invasive and noninvasive ultrasound
techniques." Hyperthermia has previously been shown to increase radiation damage
to cancerous tissue and prevent subsequent tissue repair. It has further been
shown to enhance chemotherapy and immunotherapy treatments by changing the microcirculation
and blood vessel permeability properties of a tumor. Al-Bataineh and colleagues
performed the following laboratory experiments. Using magnetic resonance imaging
(MRI) guidance, they were able to maintain desired temperature levels of 43 degrees
Celsius for 30 minutes, which is considered the optimal dose to cause the required
biological effect for hyperthermia treatment. In a related experiment, high temperature
(greater than 50 degrees Celsius) for between one to two minutes caused permanent
tissue damage to the prostate tumor. High temperature treatment appeared to induce
necrosis, or cell death. Al-Bataineh said both extreme and moderate heat appear
to have a clear effect on the tumor's cellular structure, but further research
would need to be done before any studies are conducted in humans. The research
was presented at the second AACR Dead Sea International Conference on Advances in Cancer Research: From the Laboratory to the Clinic. |
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