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Study shows link between vitamin D, skin cancer | Researchers at Henry Ford and Wayne State University
has explained a link between Vitamin D levels and basal cell carcinoma, a discovery which could lead scientists to better understand the development of the most common
form of skin cancer. In a small study, boffins found elevated levels of Vitamin
D enzymes and proteins in cancerous tissue taken from 10 patients compared to
normal skin tissue taken from them. Previous studies have linked Vitamin D deficiency
with certain cancers but this is believed to be the first time researchers looked
at Vitamin D and basal cell carcinoma. "This finding may help us in future research
to determine whether vitamin D plays a causative or reactive role in the development
and progression of skin cancer," says Iltefat Hamzavi, M.D., senior staff physician
in Henry Ford's Department of Dermatology and the study's lead author. The study
will be presented at the Photomedicine Society's annual meeting in Miami, one
day before the American Academy of Dermatology's annual meeting. Basal cell carcinoma
is the most common form of skin cancer. This cancer forms in the basal cells of
the deepest layer of the skin. Mohs micrographic surgery is one of the most effective
treatments for removing skin cancer. The 10 patients enrolled in the study were
diagnosed with basal cell carcinoma and ranged in age from 43 to 83. All had biopsies
taken of cancerous tissue and surrounding normal skin tissue. Researchers found
a 10-fold increase in Vitamin D enzyme levels and a two-fold increase in Vitamin
D protein levels. The enzymes and proteins help regulate levels of Vitamin D in
the skin. Two genes that play a role in DNA and tumor repair also had elevated
levels of Vitamin D in cancerous tissue compared to normal tissue. |
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