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High-fat ketogenic diet to control seizures 'safe, effective' | High-fat ketogenic diet used for treating current and former patients to control multiple, daily and severe seizures is not only effective, but also
appears to have no long-lasting side effects, say scientists at Johns Hopkins Children's Center. The finding has been reported in the February edition of the
journal Epilepsia. The ketogenic diet, consisting of high-fat foods and very few
carbohydrates, is believed to trigger biochemical changes that eliminate seizure-causing short circuits in the brain's signaling system. Used as first-line therapy for
infantile spasms and in children whose seizures cannot be controlled with drugs,
the diet is highly effective but complicated and sometimes difficult to maintain.
It can temporarily raise cholesterol, impair growth and, in rare cases, lead to
kidney stones, among other side effects. "Despite its temporary side effects,
we have always suspected that the ketogenic diet is relatively safe long term,
and we now have proof," says senior investigator Eric Kossoff, M.D., a pediatric
neurologist and director of the ketogenic diet program at Hopkins Children's.
"Our study should help put to rest some of the nagging doubts about the long-term
safety of the ketogenic diet," he adds. The evidence is based on a study of 101
patients ages 2 to 26 years treated with the ketogenic diet for a minimum of 16
months and for up to eight years at Hopkins Children's between 1993 and 2008.
At the time of the follow-up, patients were off the diet anywhere between eight
months and 14 years. Nearly 80 percent of the patients remained either seizure-free
or had their seizures reduced by half. Most patients' seizures did not worsen
even years after stopping the diet. |
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