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New discovery may lead to more effective stem cell therapies for leukemia | Scientists at UC San Diego say they have taken a critical first step for the development of safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, anaemia and a host of other diseases of the blood
or bone marrow. They've identified the specific region in vertebrates where adult
blood stem cells arise during embryonic development. The researchers say their
time-lapse imaging of the process, by which primitive embryonic tissues first
produce the parent stem cells that produce all adult blood cells over the life
of an individual, should help guide future efforts to repair and replace this
cell population for therapeutic purposes. Current transplantation therapies rely
on the infusion of donor stem cells into a patient's bone marrow to generate new,
healthy blood cells without disease. But that procedure is often risky and can
result in fatal complications, due in part to "graft-versus-host disease," in
which transplanted cells react against foreign tissues of the recipient. One means
of circumventing this immune rejection problem would be to generate hematopoietic
stem cells, or HSCs, using the patient's own precursor cells. Such cells would
be perfectly genetically matched, but in order to generate such cells, scientists
must first understand the molecular processes that underlie specification of HSCs.
"If we could generate healthy HSCs from patients and transplant them back into
their own bone marrow, it would eliminate many complications," said David Traver,
who headed the research team. "Our findings are an important step toward this
goal because they provide a better understanding of how HSCs, the cell type responsible
for the clinical benefits of bone marrow transplants, are first specified during
development. "This improved understanding will aid efforts to instruct pluripotent
embryonic stem cells (ESCs), the stem cells that can produce all types of tissue-specific
stem cells in the body, to make HSCs; something that is not currently possible.
In other words, we are one step closer now to understanding how to clinically
generate HSCs for cellular replacement therapies from ESCs," he added. Traver
and his colleagues made their discoveries in zebrafish, a model laboratory organism
for geneticists in which embryos are transparent, allowing the researchers to
observe and track individual stem cells with a microscope. "Using zebrafish embryos
with fluorescently labeled tissues, we were able to demonstrate that HSCs arise
directly from cells lining the floor of the dorsal aorta by imaging the process
in living embryos." The study appears in this week's early online edition of the
journal Nature. |
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