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Inflammatory bowel disease raises risk of blood clot | A British study has shown that people with inflammatory bowel disease (IBD) are at far greater risk of developing life-threatening blood clots than previously thought. IBD has been known to predispose
sufferers to blood clots (thromboembolism) for some time. Clots in the leg veins
have a mortality rate of six per cent, rising to as much as 20 per cent if the
embolism is in the lungs. Previous research has suggested that most patients who
develop thromboembolism do so when their IBD is 'active', i.e. has flared up and
they are three times more likely to have a blood clot than non-sufferers. This
has led to the use of anti-clotting drugs as standard care for patients with active
IBD who are admitted to hospital. The new research at University of Nottingham
was conducted to determine what the blood-clotting risk is to patients with IBD
who manage their flare-ups outside the hospital environment, with medical care
from primary care sources like their GP. For the study, the researchers used the
UK General Practice Research Database from November 1987 to July 2001 to compare patients with IBD with controls without the disease. They concluded that non-hospitalised sufferers with active IBD were 16 times more likely to develop a blood clot than
the general population. "Inflammatory bowel disease was associated with a roughly
three-fold increase in the risk of venous thromboembolism. Compared with the general
population while ambulatory, the risk of venous thromboembolism was increased
about 16-fold for non-hospitalised patients with active inflammatory bowel disease,"
Dr Matthew Grainge, Lecturer in the University's Department of Community Health
Sciences said. "Despite the low absolute risks during non-hospitalised periods,
these results suggest that active inflammatory bowel disease in ambulatory patients
might be a far greater risk factor for venous thromboembolism than previously
recognised," he added. The study has been published in the Lancet. |
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