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Early life stress could be risk factor for cardiovascular disease | Early life stress increases sensitivity to a hormone
known to increase blood pressure and increases your cardiovascular risk in adult life, researchers have reported. "We think early life stress increases sensitivity
to a hormone known to increase your blood pressure and increases your cardiovascular
risk in adult life," said Dr. Jennifer Pollock, biochemist in the Vascular Biology
Center at the Medical College of Georgia and corresponding author on the study
published online in Hypertension. The studies in a proven model of chronic behavioral
stress - separating rat pups from their mother three hours daily for two weeks
- showed no long-term impact on key indicators of cardiovascular disease such
as increased blood pressure, heart rate or inflammation in blood vessel walls.
But when the rats reached adulthood, an infusion of the hormone angiotensin II
resulted in rapid and dramatic increases in all key indicators in animals that
experienced early life stress. Stress activates the renin-angiotensin system which
produces angiotensin II and is a major regulator of blood vessel growth and inflammation
- both heavily implicated in heart disease. "They cannot adapt to stress as well
as a normal animal does," Dr. Pollock said. Within a few days, for example, blood
pressure was nearly twice as high in the early-stress animals. |
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