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Local anaesthetics may help in treatment of inflammatory bowel disease | Local anaesthetics might have potential therapeutic effects on inflammatory bowel disease (IBD), suggests a new study. IBD is a disease of the gastrointestinal tract,
mainly the intestines that may occur in the people who have genetic potential with a
contribution
of environmental factors. There has been no definitive medical treatment and drugs
usually help the symptoms just to relieve. Local anesthetics are used to locally
desensitise the tissues to allow surgical interventions. However, their mechanism
of action is based on their potential to inhibit neuronal activity in the area.
Since it is proposed that IBD may be a result of imbalance in the autonomic neurons
of the colon, local anesthetics have the potential to reduce the inflammation
at the site of the colon that are affected by IBD. In a recent experimental study,
investigators from Uludag University School of Medicine, Bursa, Turkey investigated
the possible therapeutic effects of local anaesthetics on IBD. They topically
applied levobupivacaine, which is a novel, long lasting local anaesthetic with
less systemic side effects onto the colonic mucosa of the rats that had had experimentally
induced IBD. The researchers used some scoring systems that evaluated the inflammation
at the site of drug application. They compared the local anaesthetics to saline
solution. They found some improvement in the degree of macroscopic inflammation
at the areas where local anaesthetics were applied; however, those findings were
not supported by microscopic findings. Nevertheless, researchers concluded that
local anaesthetics might have potential therapeutic effects on IBD based on their
findings. The study has appeared in the World Journal of Gastroenterology. |
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